Tenvir EM: Best HIV Medicine online in India

Tenvir EM  is a drug that is used as part of antiretroviral therapy in patients with HIV infection. The active substances are tenofovir and emtricitabine, which inhibit the development and replication of the virus.

Pharmacological properties

Emtricitabine - a synthetic nucleoside, an analog of cytidine, is phosphorylated by cellular enzymes to emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT), competing with the natural substrate deoxytidine 5'-triphosphate and through incorporation into the generated viral DNA, which leads to chain termination.

Tenofovir disoproxyl fumarate is a non-cyclic nucleoside phosphonate diester, an analog of adenosine monophosphate. Tenofovir disoproxyl fumarate requires prior hydrolysis of the diester to convert to tenofovir and further phosphorylation with cellular enzymes to form tenofovir diphosphate. Tenofovir diphosphate inhibits the activity of HIV-1 BT by competing with the natural substrate deoxyadenosine 5'-triphosphate and breaking the DNA chain after incorporation into DNA.

Antiviral activity.

Emtricitabine and tenofovir disoproxyl fumarate. In combined studies in which the antiviral activity of a combination of emtricitabine and tenofovir was studied in cell culture, a synergistic antiviral effect was observed.

Emtricitabine. The antiviral activity of emtricitabine relative to laboratory and donor strains of HIV was evaluated on a colony of lymphoblastoid cells (colony MAGI-CCR5) and peripheral blood mononuclear cells. The value of 50% effective concentration (EC50) was in the range of 0.0013-0.64 μmol (0.0003-0.158 mg / ml). In the course of studies of the combination of emtricitabine preparations with nucleoside reverse transcriptase inhibitors (abacavir, lamivudine, stavudine, zalcitabine, zidovudine), non-nucleoside reverse transcriptase inhibitors (delavirdine, efavirenz, nevirapine), the protease inhibitors (amprenavirvir, synfinavirin, relfinlif, nelfirafin .

Overdose

In case of an overdose, the patient should be monitored for signs of toxicity), if necessary, standard supportive treatment should be used.

Tenofovir can be excreted by hemodialysis, the median clearance of tenofovir is 134 ml / min.

The withdrawal of tenofovir using peritoneal dialysis has not been investigated.

Interaction with other drugs

Based on the results of in vitro experiments and the known route of tenofovir withdrawal, the possibility of interactions mediated by CYP450 involving tenofovir and other drugs is low.

Concomitant use is not recommended.

Tenvir  should not be administered with other medicines containing tenofovir disoproxil fumarate.

Release form

Tablets 30 pieces per pack.

Structure

Active ingredients: tenofovir disoproxil fumarate and emtricitabine;

1 coated tablet contains 300 mg tenofovir disoproxyl fumarate (equivalent to 245 mg tenofovir disoproxil) and 200 mg emtricitabine.

Excipients: lactose monohydrate, croscarmellose sodium; microcrystalline cellulose, corn starch; magnesium steadrate opadri blue II 32K80963 (lactose monohydrate, hypromellose E 464, titanium dioxide E 171; triacetin; indigo aluminum E 132).

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